Degenerating heart valves: fill them up with filamin?

Developmental basis for filamin-A-associated myxomatous mitral valve disease.

AIMS We hypothesized that the structure and function of the mature valves is largely dependent upon how these tissues are built during development, and defects in how the valves are built can lead to the pathological progression of a disease phenotype. Thus, we sought to uncover potential developmental origins and mechanistic underpinnings causal to myxomatous mitral valve disease. We focus on ...

Pregnancy Outcome with Intracytoplasmic Sperm Injection Method in a Woman with Prosthetic Heart Valves

There is an increased risk of thromboembolism, anticoagulant-related hemorrhage, fetal-wastage and congestive cardiac failure in pregnant women with mechanical heart valves. In order to have a good outcome, the care of such patients must necessarily be multidisciplinary and in a well- equipped centre with adequate support services .One such patient who had mechanical mitral and aortic valves re...

Vibrational analysis of bioprosthetic heart valve leaflets using numerical models: effects of leaflet stiffening, calcification, and perforation.

The fundamental natural frequency of the closed cusps of porcine bioprosthetic valves, fabricated from the normal leaflets of pig aortic valves, was estimated using a finite element model. Both normal and stiffened leaflets were considered in the vibrational analysis. The effects of conditions that simulated degeneration, such as stiffening, central perforation, a tear, calcium deposits in the ...

Anti-Coagulation During Pregnancy in Women with Mechanical Heart Valves: A Prospective Study

A survey on the prevalence of heart murmurs in polo horses

Background: Cardiac murmur and subsequently cardiac failure is one of the poor-performance causes in athletic horses. Attention to murmur character is vital during heart examination. Polo is a sport which demands very high stress on horses, which may result in more stress on cardiovascular system. Objectives: In this study we assume that high pressure on polo horses makes them more susceptible ...